DAMI Cell Line
نویسندگان
چکیده
منابع مشابه
Characterization of a new megakaryocytic cell line: the Dami cell.
A new human megakaryocytic cell line (Dami) has been established from the blood of a patient with megakaryoblastic leukemia. The Dami cells grow primarily in suspension with a doubling time of 24 to 30 hours. By light and electron microscopy, the Dami cells range in size from 12 to 120 micron in diameter and have lobulated nuclei characteristic of megakaryocytes. At least 89% of the cells react...
متن کاملOverexpression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest.
The maturation of megakaryocytes in vivo requires polyploidization or repeated duplication of DNA without cytokinesis. As DNA replication and cytokinesis are tightly regulated in somatic cells by cyclins and cyclin-dependent kinases, we sought to determine the pattern of cyclin gene expression in cells that undergo megakaryocytic differentiation and polyploidization. The Dami megakaryocytic cel...
متن کاملThe effect of amifostine on differentiation of the human megakaryoblastic Dami cell line
Amifostine is a cytoprotective drug that was initially used to control and treat nuclear radiation injury and is currently used to provide organ protection in cancer patients receiving chemotherapy. Clinical studies have also found that amifostine has some efficacy in the treatment of cytopenia caused by conditions such as myelodysplastic syndrome and immune thrombocytopenia, both of which invo...
متن کاملThe 1.35-kb and 7.5-kb Duffy mRNA isoforms are differently regulated in various regions of brain, differ by the length of their 5' untranslated sequence, but encode the same polypeptide.
between HEL and Dami represent tumoral heterogeneity already present REFERENCES within the original passages from which HEL, and ultimately Dami, were 1. Handin RI: Dami cell line. Blood 89:4238, 1997 (letter) established. Subclonal divergence would also fit several reports describing 2. Greenberg SM, Rosenthal DS, Greeley TA, Tantravahi R, Hanphenotypic differences between Dami and HEL. For th...
متن کاملEstablishment a CHO Cell Line Expressing Human CD52 Molecule
Background: CD52 is a small glycoprotein with a GPI anchor at its C-terminus. CD52 is expressed by Normal and malignant T and B lymphocytes and monocytes. There are detectable amounts of soluble CD52 in plasma of patients with CLL and could be used as a tumor marker. Although the biological function of CD52 is unknown but it seems that CD52 may be involved in migration and activation of T-cells...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1997
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v89.11.4238